William O'Connell, PMP
Seattle, WA | (206) 551-5524 | WilliamOConnellPMP@gmail.com | LinkedIn | Resume

Enterprise Cloud Delivery · Life Sciences & Regulated Environments · AWS CertifiedEngagement Manager · Senior TPM · AI Safety · Risk Mitigation as a Discipline

Available: Contract & FTE · Engagement Manager · Senior TPM · Life Sciences · AI Safety · AWS SAA · PMP · Seattle / Remote

Engagement Manager and Senior Technical Program Manager with 20+ years of enterprise delivery at scale — including 14 years at Roche/Genentech as consultant then converted FTE Delivery Head, directing infrastructure transformation, cloud migrations, and portfolio governance across North America and APAC. Eight of those years I operated as an external consultant: walking into one of the world's most regulated life sciences environments, earning trust quickly, and delivering outcomes that held up under FDA scrutiny.

I have directed $100M+ programs, led 100,000-user global migrations, and managed $25M annual portfolios across 25+ concurrent programs with zero unplanned downtime. In 2025 I completed a deliberate cloud and AI certification sprint, built two production AWS serverless systems, and deployed an AI Conversational Safety Layer on Amazon Bedrock and Claude with deterministic guardrails, RBAC enforcement, and structured audit logging. Both systems are live at this site.

My discipline: Safety controls and operational rigor are not compliance overhead — they are engineering requirements. That philosophy, developed across GxP-regulated systems where a missed control has patient consequences, applies equally to AI infrastructure where a degraded safety pipeline can be invisible and catastrophic. The result: zero unplanned downtime, zero compliance findings, delivery at scale.

Delivery Track Record:$100M+ delivery100K+ users migrated$20M+ cloud savings100+ resources led